Ophirapstanol trisulfate, a new biologically active steroid sulfate from the deep water marine sponge Topsentia ophiraphidites

S P Gunasekera; S H Sennett; M Kelly-Borges; R W Bryant

doi:10.1021/np50114a024

Ophirapstanol trisulfate, a new biologically active steroid sulfate from the deep water marine sponge Topsentia ophiraphidites

J Nat Prod. 1994 Dec;57(12):1751-4. doi: 10.1021/np50114a024.

Authors

S P Gunasekera¹, S H Sennett, M Kelly-Borges, R W Bryant

Affiliation

¹ Harbor Branch Oceanographic Institution, Inc., Fort Pierce, Florida, USA.

PMID: 7714543
DOI: 10.1021/np50114a024

Abstract

Ophirapstanol trisulfate [1], a new steroid trisulfate related to sokotrasterol trisulfate was isolated from a deep water marine sponge Topsentia ophiraphidites. Compound 1 exhibited significant inhibition in the guanosine diphosphate/G-protein RAS exchange assay. The structure elucidation of 1 and ophirapstanol [2] by nmr spectroscopy is described.

MeSH terms

Animals
Circular Dichroism
Genes, ras / drug effects
Humans
Magnetic Resonance Spectroscopy
Mutagenicity Tests
Mutagens / isolation & purification*
Mutagens / toxicity
Porifera / chemistry*
Sterols / isolation & purification*
Sterols / toxicity
Sulfuric Acid Esters / isolation & purification*
Sulfuric Acid Esters / toxicity

Substances

Mutagens
Sterols
Sulfuric Acid Esters
ophirapstanol trisulfate